Propose: Vesicovaginal fistula (VVF) has
remained one of the difficult challenges to surgical therapy. In this study,
autologous platelet-rich plasma (PRP) and platelet-rich fibrin glue (PRFG) has
been used for VVF closure as a minimally invasive approach.
Materials and Methods: The data including age, parity, ICIQ- UI, ICIQ- QOL,
duration of leakage, the diameter of fistula and complications were collected
before and after intervention. PRP & PRFG was prepared from 12 patients’
own blood. Deepithelialisation was performed around the fistula till a small
amount of hemorrhage was occurred; PRP was injected around the fistula into the
tissue and PRFG was interpositioned in the tract.
Results: No complications were observed during and after the injection.
Mean age was 39.83±8.40 years. At 3-months' follow up, 11 patients considered
themselves clinically cured; transvaginal physical examination and cystography
was normal in 11 patients. ICIQ-UI and ICIQ-QOL showed remarkable improvement
in 11 patients. One patient had significant improvement, but did not consent to
the second injection. None of the patients had voiding dysfunction, urinary
incontinence or retention or urinary tract infection.
Conclusions: Autologous PRP injection and PRFG interposition offers a safe,
effective and novel minimally invasive approach for VVF treatment which
obviates the need for open surgery. We would like to call this technique